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Why Investors Are Betting On Psychedelics

Investors Are Betting On Psychedelics

While they’ve historically brought the risk of long jail sentences, psychedelics are now bringing another long-term scenario: big-time investments.

The potential for psychedelics in treating mental disorders such as depression, suicidal thoughts, PTSD, and anxiety, is bringing interest from Wall Street.

Dozens of biopharmaceutical companies are exploring investment opportunities to further develop the psychedelic marketplace. Many companies are working on synthesizing active compounds, which will make psychedelic drugs more accessible, particularly for clinical use.

“There is a smaller subset of investing verticals in the psychedelic space as it is more of an intellectual property race to develop drugs,” Michael Sobeck, managing partner at Ambria Capital, a San Juan, Puerto Rico-based asset manager told Ellen Chang of U.S. News & World Report.

According to Tania Gonsalves, analyst for Canaccord Genuity Capital Markets, the estimated market size for psychedelics may be $100 billion. She says the companies that will emerge as the winners “will have deep pockets, patentable products and a well-thought-out reimbursement strategy.”

The industry value is buoyed by more than a dozen clinical trials currently underway in the U.S., including trials at the Johns Hopkins Center for Psychedelic & Consciousness Research.

Several companies have already launched IPOs including Janssen (part of JNJ) and MindMed. The former is working on a ketamine therapy with FDA approval for treatment-resistant depression. MindMed is developing a non-hallucinogenic molecule based on ibogaine for use in treating opioid addiction. It counts Kevin O’Leary of “Shark Tank” as one of its investors.

While many of these drugs are still illegal under the U.S. Schedule 1classification, local governments are easing restrictions. Denver recently passed legislation decriminalizing possession and use of psilocybin aka “magic mushrooms.”

This step could also lead the state to eventual legalization, and a recreational market much like its booming cannabis industry. November will see Oregon and Washington DC ballot measures on decriminalization for substances including psilocybin, ibogaine, DMT, and mescaline.

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  • MindMed Releases LSD for Anxiety Data ! (MNMD, MMED)

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    In today’s episode, we discuss MindMed (Nasdaq: MNMD, NEO:MMED) and its Phase 2 LSD Trial Treating Anxiety Results.

    MindMed (Nasdaq: MNMD, NEO:MMED) finally gave the world a glimpse into its LSD-as-medicine project today.

    Speaking at the highly anticipated PSYCH Symposium in London, researchers Prof. Matthias Liechti and Dr. Friederike Holze presented topline data of a Phase 2, double-blind, placebo-controlled study, attempting to treat anxiety disorders with LSD in 46 patients. Patients received 200 µg (micrograms) of LSD, which is considered a large dose.

    The results were very positive, though perhaps not paradigm shifting — yet.

    The primary endpoint of the study was the reduction in anxiety levels 16 weeks after the administration of LSD. They measured this using a questionnaire called the State Trait Anxiety Inventory, better known by its acronym STAI. In short, a person can have a score between 0 and 63, with the higher the score, the worse the anxiety.

    The study found that 65% of patients saw their anxiety levels drop by at least 30% from where they were before treatment, 16 weeks after dosing. This compared to only 9% of patients in the placebo arm reaching that 30% level. The average reduction in the STAI was 16.2 points.

    Importantly, there was only one serious adverse event in the trial, which consisted of “acute transient anxiety and delusions” during the LSD experience. It does not appear that this patient had any troubles once the effects wore off. In sum, the administration of large doses of LSD appears to be very safe, even if one person did have a particularly bad experience during the dosing.

    Furthermore, when looking at secondary variables that measure depression, anxiety and other major psychiatric symptoms (Hamilton Depression Scale, Beck Depression Index, Symptom-Check-List-90-R) the results “showed similarly rapid and sustained responses consistent with a lasting treatment effect.”

    In sum, according to MindMed, the topline data demonstrates “the significant, rapid, durable, and beneficial effects of LSD and potential to safely mitigate symptoms of anxiety and depression.”

    Interested in reading the article? Click here: 👇

    MindMed’s Phase 2 LSD Trial Treating Anxiety Was a Success
    https://psychedelicspotlight.com/mindmed-lsd-anxiety-phase-2-trial-psych-symposium/

    #MindMed #Anxiety #MNMD